Are you cancer? Find your cancer trial! Apply now

Are there any new treatments or clinical trials available for bladder cancer?

Are there any new treatments or clinical trials available for bladder cancer?

June 27, 2024
Forum / Cancer Community › Category: Bladder Cancer › Are there any new treatments or clinical trials available for bladder cancer?
2 Vote Up Vote Down
Avatar photoCTF Help Staff asked 1 year ago
Recent advancements in bladder cancer treatment have led to new therapeutic options and clinical trials. Here are some of the latest developments:

1. Enfortumab Vedotin and Pembrolizumab (EV/Pembro) Combination

  • Description: This combination of an antibody-drug conjugate (enfortumab vedotin) and an immunotherapy drug (pembrolizumab) has shown significant promise in treating advanced urothelial bladder cancer.
  • Results: Clinical trials have demonstrated that this combination nearly doubles the overall survival rate compared to standard chemotherapy, with a median survival of 31 months versus 16 months.
  • Approval: The FDA approved this combination as a first-line treatment for advanced urothelial cancer.
  • Sources: National Cancer Institute​ (Comprehensive Cancer Information)​, Johns Hopkins Medicine​ (Home)​.

2. Nogapendekin Alfa Inbakicept (Anktiva) with BCG

  • Description: Anktiva, an immune-boosting drug, used in combination with Bacillus Calmette-Guérin (BCG), an established immunotherapy for non-muscle invasive bladder cancer.
  • Results: This combination has been approved by the FDA based on clinical trials showing improved outcomes for patients who did not respond to BCG alone.
  • Sources: UCLA Health​ (Welcome to UCLA Health)​, Dana-Farber Cancer Institute​ (Dana-Farber Cancer Institute)​.

3. Cretostimogene Grenadenorepvec

  • Description: A novel immunotherapy involving a cancer-killing virus delivered into bladder cells, currently in phase 3 clinical trials.
  • Usage: Aimed at patients with BCG-unresponsive, non-muscle invasive bladder cancer.
  • Results: Early trials have shown promising results with good tolerance and significant cancer control.
  • Sources: Mayo Clinic​ (Mayo Cancer Blog)​, Dana-Farber Cancer Institute​ (Dana-Farber Cancer Institute)​.

4. Single-Port Robotic Cystectomy

  • Description: A minimally invasive surgical technique for bladder removal, offering potential benefits such as less pain and quicker recovery.
  • Usage: Applied to muscle-invasive bladder cancer and some cases of non-muscle-invasive bladder cancer that have not responded to other treatments.
  • Sources: Mayo Clinic​ (Mayo Cancer Blog)​.

5. Natural Killer (NK) Cell Therapy

  • Description: This therapy involves boosting the body’s natural killer cells to fight bladder cancer. It is being tested in combination with interleukin-15 stimulants.
  • Usage: Currently under investigation in clinical trials for advanced bladder cancer.
  • Sources: Dana-Farber Cancer Institute​ (Dana-Farber Cancer Institute)​.

6. Docetaxel and Gemcitabine Combination

  • Description: This combination is being tested as an alternative to BCG for patients with BCG-naïve high-grade non-muscle invasive bladder cancer.
  • Results: The BRIDGE trial is evaluating its effectiveness and aims to provide a new first-line therapy option.
  • Sources: Memorial Sloan Kettering Cancer Center​ (Memorial Sloan Kettering Cancer Center)​.
These developments represent a significant leap forward in bladder cancer treatment, offering new hope and improved outcomes for patients. For those interested in participating in clinical trials or learning more about these treatments, consulting with healthcare providers and cancer centers is recommended.
4 Answers
0 Vote Up Vote Down
Christopher answered 1 year ago

There are new treatments and trials available for bladder cancer, including PSMA-targeted therapies and the combination of Nogapendekin Alfa Inbakicept with BCG, which is especially useful for patients who didn't respond to BCG alone. Immunotherapy advancements, like Cretostimogene Grenadenorepvec, are also showing promise in ongoing trials.

Always consult with your oncologist to understand which of these options might be suitable for your condition and to explore available clinical trials.

0 Vote Up Vote Down
jessica_1974 answered 1 year ago

For those battling bladder cancer, new treatment options are emerging. Enfortumab Vedotin combined with Pembrolizumab has shown impressive results in clinical trials, improving survival rates. Another promising therapy is Nogapendekin Alfa Inbakicept with BCG, approved for patients who did not respond to BCG alone. Exploring clinical trials for treatments like Cretostimogene Grenadenorepvec can also provide access to cutting-edge therapies.

Discuss these with your doctor to see if you might benefit from these advancements.

0 Vote Up Vote Down
Sarah Kandi answered 1 year ago

Recent advancements in bladder cancer treatments have introduced several new options. The EV/Pembro combination, involving enfortumab vedotin and pembrolizumab, has nearly doubled overall survival rates compared to standard chemotherapy.

Another exciting development is Cretostimogene Grenadenorepvec, a novel immunotherapy currently in phase 3 trials. It's important to discuss these new treatments with your healthcare provider to see if you qualify for any clinical trials.

Staying informed and exploring all options is key in managing bladder cancer.

0 Vote Up Vote Down
Matthew answered 1 year ago

Yes, there are several promising new treatments and clinical trials for bladder cancer. One notable treatment is the combination of Enfortumab Vedotin and Pembrolizumab, which has shown significant improvement in survival rates for advanced urothelial bladder cancer.

Additionally, Nogapendekin Alfa Inbakicept (Anktiva) combined with BCG is effective for patients who didn't respond to BCG alone. Exploring these options with your doctor is crucial as they can provide personalized advice based on your specific case.

[vc_row full_width="stretch_row" background_color="secondary"][vc_column][vc_row_inner][vc_column_inner width="2/5"][tm_spacer size="lg:60"][tm_image image="2828"][tm_spacer size="lg:40"][tm_heading tag="div" custom_google_font="" text="You are not alone! The Cancer Trial Foundation Help (CTF Help) is dedicated to providing the support and care you need. Our foundation focuses on facilitating access to clinical trials conducted by international pharmaceutical companies, offering more opportunities for innovative treatments. We understand the growing needs of our community and strive to meet them by connecting patients with advanced clinical trials. "][tm_spacer size="lg:42"][/vc_column_inner][vc_column_inner width="1/5"][/vc_column_inner][vc_column_inner width="2/5"][tm_spacer size="lg:60"][tm_heading custom_google_font="" text_color="custom" custom_text_color="#ffffff" text="Useful Links"][tm_spacer size="lg:42"][tm_custom_menu style="2" link_hover_color="primary" nav_menu="footer-useful-links"][tm_spacer size="lg:10"][/vc_column_inner][/vc_row_inner][tm_spacer size="lg:10"][vc_separator color="custom" accent_color="rgba(255,255,255,0.08)"][vc_row_inner content_placement="middle" lg_spacing="padding_top:27;padding_bottom:27"][vc_column_inner width="1/2"][tm_heading tag="div" custom_google_font="" text="© 2024, BM, All rights reserved."][tm_spacer size="xs:30"][/vc_column_inner][vc_column_inner width="1/2"][easy-social-share buttons="facebook,twitter,linkedin,mail,reddit,whatsapp,telegram" style="icon" template="17" nospace="yes" flex="yes"][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row]

Hit enter to search or ESC to close